NANOTECHNOLOGY FOR CANCER THERAPY: RECENT DEVELOPMENTS

Roshan Telrandhe*

ABSTRACT

This paper is an overview of advances and prospects in applications of nanotechnology for cancer treatment. Nanotechnology is an use for prevention, diagnosis, and treatment .nanotechnology offer a promise for the targeted delivery of drugs, genes and protein to tumer tissue and therefore alleviating the toxicity of anticancer agent in healthy tissues. Cancer is one of the leading causes of death worldwide. Deaths from cancer are continuously rising worldwide with a projection of about 12 million deaths from cancer in 2030. . Nanotechnology is one of the most rapidly growing fields in the 21st century. Many different types of nanosystems have been utilized in diagnostics and therapeutics of various diseases. To subside the disadvantages of conventional cancer therapeutics, nanotechnology has been given considerable attention. In this paper, the current nanotechnologies that can be utilized in oncological interventions will be discussed. These mainly include arrays of nanocantilevers, nanotubes and nanowires for multiplexing detection, multifunctional injectable nanovectors for therapeutics and diagnostics. It is demonstrated how nanotechnology can help solve one of the most challenging and longstanding problems in medicine, which is how to eliminate cancer without harming normal body tissue. This article review current nanotechnology platforms for anticancer drug delivery, including polymeric nanoparticles, liposomes, dendrimers, nanoshells, carbon nanotubes,superparamagnetic nanoparticles and nuclear acid base nanoparticle [DNA, RNA interference (RNAi), and antisense oligonucleotide (ASO) ] as well as nanotechnologies for combination therapeutics strategies, for example, nanotechnologies combined with multidrug-resistance modulator, ultrasound, hyperthermia, or photodynamic therapy. The review increases awarnes of advantages in cancer therapy.

Keywords: Nanotechnology; Cancer, Nanoparticles, Nanoectors, Liposomes, Nanobiosensors, Dendrimers, nanoshell, quantum dot, diamondoid, nanocantilevers, Nanowires ,Fullerenes ,Nanotubes and Superparamagnetic nanoparticles.