EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PHARMACOLOGICAL ASSESSMENT OF DELONIX REGIA FLOWERS FOR HEPATOPROTECTIVE ACTIVITY AGAINST PARACETAMOL-INDUCED LIVER TOXICITY

Abubaker Siddiq*, Moulya M.V, Siraj Ahamed S and Bharathi D.R

ABSTRACT

The objective of this study is to assess hepatoprotective activity of ethanolic extract of Delonix regia flowers (EEDRF) against Paracetamol induced hepatotoxicity in Rats. The toxicity were induced in rats by paracetamol 2g/kg orally, in four groups of rats (two test, standard and toxic control). Two test groups received EEDRF at doses of 250 mg/kg and 500 mg/kg. Standard group received silymarin (100 mg/kg) and toxic control received only Paracetamol. Control group received only vehicle. On 7th Day animals were sacrificed and liver enzymes like Serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT), Serum alkaline phosphatase (ALP), Serum total and direct bilirubin were estimated in blood serum and invivo antioxidant enzymes like Tissue Glutathione (GSH), lipidperoxidation(LPO) and superoxide dismutase(SOD) were estimated in tissue homogenate. The ethanolic extract produced significant reduction in SGPT, SGOT, ALP, total and direct bilirubin, LPO levels and significantly increased the depleted GSH and SOD levels as compared with Paracetamol group. This is further confirmed by histopathological studies. The results of the present study reveal that EEDRF has contributed to the reduction of oxidative stress and the protection of liver in experimental animals.

Keywords: Delonix regia, Paracetamol, Silymarin, hepatoprotective, Lipid peroxidation.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )