THE FEATURES OF THE IMMUNE STATUS OF CHILDREN WITH CHRONIC OBSTRUCTIVE BRONCHITIS ON THE BACKGROUND OF CYSTIC FIBROSIS

Fayzullaeva N.Ya.*, Shamsiev F.M. and Musakhodjaeva D.A.

ABSTRACT

Background: Despite of the complex organization and the perfection of the defense mechanisms of the mucous membranes, various pathogens overcome all barriers and penetrate into the internal environment of the body and cause disease. This may contribute to a variety of internal and external factors that have an adverse effect on the mucous membranes of the respiratory tract and its defense mechanisms. Objective: The aim of the study was to examine the features of immunological reactivity in chronic obstructive bronchitis in children with and without cystic fibrosis. Methods: Determined lymphocytes with CD3, CD4, CD8, CD16, CD20, CD25, CD HLA-DR, CD95 phenotypes. It was held an examination of 56 children with chronic obstructive bronchitis (COB). Of these, In 18 children experienced COB on the background of cystic fibrosis. Result: Carried immunological studies have shown that the presence of cystic fibrosis exacerbate immunodeficiency Children with COB, who significantly reduced the level of T-lymphocytes and subpopulation of CD4 + - and CD8 + cells, while the level of B lymphocytes was increased. Conclusion: The results showed that the development of immunopathological conditions in children with chronic obstructive bronchitis on the background of cystic fibrosis has its own characteristics, and to a greater extent due to the insolvency of a functional immune cells.

Keywords: Chronic obstructive bronchitis, cystic fibrosis, immune system.