EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

UMBILICAL CORD THROMBOSIS: A METICULOUS CULPRIT OF INTRAUTERINE FETAL DEMISE

Samantha Stancu MD*, Cristian Poalelungi MD, PhD, Bogdan Carabas MD, Manuela Russu MD, PhD Professor of Obstetrics and Gynaecology

ABSTRACT

Introduction: Intrauterine fetal demise (IUFD) is the most dramatic and often unpredictable pregnancy complication. Sixty percent of cases remain idiopathic despite numerous pathophysiological entities described in literature. The objective of this study was to identify potential risk factors and causes of IUFD. Materials and Methods: A retrospective, observational study conducted on pregnant women, who experienced a fetal loss at gestational age ≥ 24 weeks and birth weight ≥ 500 grams, at the Obstetric Discipline of Dr. I Cantacuzino Hospital. Data concerning demographics, maternal-associated pathology, delivery, fetal gender and birth weight, as well as autopsy findings were procured for the period between January 1, 2013 and December 31. Statistical analysis was carried out using GraphPad Prism with statistical significance set at p<0.05. Results and Discussion: Forty-three fetal losses were recorded in women ages 16-42 (average age 28.2 ± 6.4 years). Twelve mothers (27.9%) consented to fetal autopsy, which revealed the following causes of death: umbilical cord thrombosis (n=7, 63.9%), subchorionic thrombosis (n=2, 18.2%) and vasa praevia (n=2, 18.2%). Negative Docimasia tests placed time of death as antepartum in all autopsied fetuses. Cerebral hemorrhage was the most frequent autopsy finding (n=8, 72.7%). The following risk factors for umbilical cord thrombosis were identified: previous Caesarean Section (p=0.0006), lack of pregnancy monitoring (p=0.0006) and excessive gestational weight gain (p=0.003). Conclusion: Umbilical cord thrombosis is an increasingly frequent cause of spontaneous IUFD. Multicentric randomized controlled trials are needed to establish guidelines for anticoagulation in pregnancy. All pregnant women with abnormal coagulation parameters should be screened for thrombophilia.

Keywords: intrauterine fetal demise, umbilical cord thrombosis, autopsy.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )