EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANTI-INFLAMMATORY EFFECT, ANTIOXIDANT POTENTIALS AND PHYTOCHEMICAL INVESTIGATION OF CRATAEGUS SINAICA BOISS. ROOTS GROWING IN EGYPT.

Atef A. El-Hela, *, Nevein M. Abdelhady, Hala M. El-Hefnawy, Taghreed A. Ibrahim and Gamil M. Abdallah

ABSTRACT

In vivo antioxidant and anti-inflammatory studies of the aqueous and methanol extracts, as well as, methylene chloride and ethyl acetate fractions of Crataegus sinaica Boiss. roots (Rosaceae) growing in Egypt were carried out. Anti-inflammatory effect was evaluated in rats using paw oedema ,which revealed that the methylene chloride fraction was the most potent followed by methanol extract, ethyl acetate fraction and aqueous extract respectively, meanwhile, the antioxidant potentials was performed through evaluation of their impact against Streptozotocin induced oxidative stress in liver and kidney tissues of albino rats revealed that the ethyl acetate fraction was the most potent followed by methanol and aqueous extracts, then methylene chloride fraction respectively. Phytochemical investigation of the methylene chloride and ethyl acetate fractions exhibiting the most significant anti-inflammatory and antioxidant effects resulted in isolation of four compounds, namely, cholesterol, ß-sitosterol, uvaol and oleanolic acid, and five compounds, namely, epicatechin, quercetin, hyperoside, rutin and vitexin respectively, the structures of the isolated compounds were elucidated on basis of their chromatographic and spectroscopic data.

Keywords: Crataegus sinaica Boiss., Egypt, Roots, Triterpenes, Flavonoids, Anti-inflammatory and Antioxidant.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )