EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

EVALUATION OF ADHERENCE AND DETERMINANTS OF ADHERENCE TO HIGHLY ACTIVE ANTIRETROVIRAL THERAPY AMONG HIV-INFECTED ADULTS AND ADOLESCENTS ATTENDING A NIGERIA TEACHING HOSPITAL TREATMENT CENTRE

Sani Ibn Yakubu*, Erick Wesley Hedima, Nasiru Yakubu Ikunaiye, Micheal Samuel, Adeyemi Abdul-basit Haliru

ABSTRACT

The objective of this study was to evaluate adherence and determinants of adherence to highly active antiretroviral therapy (HAART) among HIV-infected adults and adolescents attending a Nigeria Teaching Hospital Treatment Centre. Method: An expert validated 41-item structured questionnaire (Cronbach alpha of 0.709) was administered to 400 HIV-infected adolescents and adults. The questionnaire was divided in to three parts: the first part was directed at the socio-demographic characteristics of the respondents, the second and the third parts were designed to assess respondents’ adherence to HAART and the knowledge of the respondents on HIV infection as well as on HAART respectively. Results: The results revealed that female respondents (71.5%) were significantly (p < 0.001) more than male respondents (28.5%) with comparable level of education attained between the gender (p = 0.376). Most of the respondents (34%) were unemployed with females more than males (p < 0.001) and the majority of the respondents were married. A total of 236 (59.0%) of the respondents achieved ≥ 95% adherence by pharmacy records with both gender having comparable adherence. Only 2% and 1.5% of the respondents achieved ≥ 95% adherence by self-report and pooled adherence respectively. Conclusion: Overall, the adherence rates were very poor in this setting. Patients’ residence from the treatment centre and knowledge on HAART were the factors that correlate with adherence. Counselling, knowledge, years on HAART and complexity of regimen were predictors of pooled adherence among the patients. Furthermore, demographic and socio-economic factors like: gender, level of education, marital status, income and occupation have influence on adherence.

Keywords: Adherence, HAART, HIV-infected, knowledge, pooled adherance.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia