( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



EL-Shahat A. Toson*, Gamal E. Shiha, EL-Sherbiny H. EL-Saied, Waleed Samir, Mohamed ELbasiony, Doaa A. Shoieb


Background: Chronic hepatitis B virus run the risk of developing fibrosis and in later life hepatocellular carcinoma. Aim: The aim is to test the diagnostic power of YKL-40 in assessing liver fibrosis and its ability to improve those of APRI, AGE/AST, AAR, FI, CDS, LOK, API, FIB4, FIBQ, GUCI and KING scores in the previous patients. Methods: Blood samples for complete blood count and serum for YKL-40, liver function tests, HBV DNA and HBV markers evaluation were taken (n=71, F0 - F4); beside, transient elastography. The numerical values of these scores were quantized and correlated with that of YKL-40. Results: YKL-40 can efficiently differentiate patients with non-significant (F0, F1) from those with significant fibrosis (F2 –F4); sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 86, 100, 100, 87 and AUC of 0.941, respectively and those with severe (F3 , F4) from non-severe fibrosis (F0 – F2, 95, 74, 60, 97 and 0.932, respectively). The additions of the results of YKL-40 to those of the previous scores greatly enhance their AUCs and their diagnostic power in the majority of cases. Conclusions: YKL-40, itself, cannot only help in assessing hepatic fibrosis but also dramatically enhance the diagnostic power of the tested scores in their non-invasive abilities to discriminate the stages of the disease in HBV chronically infected Egyptian patients.

Keywords: YKL-40, Liver fibrosis, Hepatitis B Virus, transient elastography, non-invasive scores.

[Full Text Article]



  • New Issue Published

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    JANUARY Issue has been successfully launched on 1 January 2022.

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    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )