EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ARE STILL FIDUCIAL MARKERS ALONE APPROPRIATE IN THE IMAGE GUIDED ERA FOR PROSTATE CANCER RADIOTHERAPY? A SINGLE INSTITUTION EXPERIENCE BASED ON A “WELL TRAINED” PATIENT SUBGROUP.

Simona Allis MD*, Riccardo Ragona PhD, Silvia Maria Anglesio PhD, Andrea Ricci MD,
Francesco Porpiglia MD, Marco Cossu MD, Alessia Reali MD, Gianluca Mortellaro and Maria Grazia Ruo Redda MD

ABSTRACT

Purpose: The purpose of this work is to assess the consistency of Fiducial Markers (FM) based IGRT in clinical practice and the magnitude of daily prostate gland displacements in a subgroup of patients carefully trained to maintain a constant and reproducible organ filling. Methods: A physician trained each patient in this selected 55 patients group, assuring a highly reproducible and well-administered self-preparation. Three FMs were implanted using a transrectal ultrasound technique. IGRT was achieved by daily single exposure MV portal images and, every 6 treatment sessions, double exposure portal images were acquired in order to evaluate differences in displacements between fiducial markers and bony structures. Results: There were no grade 3-4 complications (e.g. infections, bleeding or abscess) or significant patient reported discomfort related to FM insertion. Differences in displacements between FM and bony landmark resulted to be statistically significant (p<0,05), relating to a good self preparation. Displacement recorded during first five treatment sessions are not predictive of movement directions during remaining fractions. Conclusions: FMs give the opportunity, even in centers not equipped with in-room volumetric imaging systems, to perform IGRT. FMs-IGRT in combination to high quality patient rectal and bladder preparation allows an improvement of dose delivery and local control while reducing radiotherapy-related toxicity and overall treatment time. Images control has to be carried out every day in order to be clinically useful as displacements occur in random directions.

Keywords: 1. Prostate Cancer, 2. Radiotherapy, 3. Fiducial Markers, 4. Rectal filling, 5. Bladder Filling.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )