EVALUATION OF ANTI-ULCER ACTIVITY OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE FILM IN WISTAR RATS WITH GASTRIC ULCERATION INDUCED BY INDOMETHACIN

Sonia Narwal*, Vipin Saini, Vichitra Kaushik

ABSTRACT

The present study aimed to evaluate the anti-ulcer activity of Esomeprazole magnesium trihydrate by using models of acute gastric lesions in Wistar rats induced by indomethacin and inhibition of gastric cyclo-oxygenase resulting in less formation of prostacyclin. Groups of 4-6 Wistar rats are used. The test drugs are administered orally in 0.1% Tween 80 solution 10 min prior to oral indomethacin in a dose of 20 mg/kg (4 mg/ml dissolved in 0.1% Tween 80 solution). Test drug Esomeprazole magnesium trihydrate and standard drug Misoprostol both are used in a dose of 30mg/kg. Formal-saline (2% v/v) is also injected into the totally ligated stomachs for storage overnight The results showed that Macroscopical and Histopathological changes on Indomethacin induced model showed the edematous, inflammation, degeneration, hemorrhage, appearance of the gastric tissue, where as Esomeprazole magnesium trihydrate (30 mg/kg) treated groups shows regeneration and prevents the formation of hemorrhage and edema. It is conclude that Esomeprazole magnesium trihydrate has good antiulcer activity and high effective in ulcers induced by indomethacin

Keywords: Esomeprazole Magnesium trihydrate, Wister rats, Ulcer-Index, Indomethacin, Anti -ulcers.