EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

EVALUATION OF ANTI-ULCER ACTIVITY OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE FILM IN WISTAR RATS WITH GASTRIC ULCERATION INDUCED BY INDOMETHACIN

Sonia Narwal*, Vipin Saini, Vichitra Kaushik

ABSTRACT

The present study aimed to evaluate the anti-ulcer activity of Esomeprazole magnesium trihydrate by using models of acute gastric lesions in Wistar rats induced by indomethacin and inhibition of gastric cyclo-oxygenase resulting in less formation of prostacyclin. Groups of 4-6 Wistar rats are used. The test drugs are administered orally in 0.1% Tween 80 solution 10 min prior to oral indomethacin in a dose of 20 mg/kg (4 mg/ml dissolved in 0.1% Tween 80 solution). Test drug Esomeprazole magnesium trihydrate and standard drug Misoprostol both are used in a dose of 30mg/kg. Formal-saline (2% v/v) is also injected into the totally ligated stomachs for storage overnight The results showed that Macroscopical and Histopathological changes on Indomethacin induced model showed the edematous, inflammation, degeneration, hemorrhage, appearance of the gastric tissue, where as Esomeprazole magnesium trihydrate (30 mg/kg) treated groups shows regeneration and prevents the formation of hemorrhage and edema. It is conclude that Esomeprazole magnesium trihydrate has good antiulcer activity and high effective in ulcers induced by indomethacin

Keywords: Esomeprazole Magnesium trihydrate, Wister rats, Ulcer-Index, Indomethacin, Anti -ulcers.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia