EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ASSOCIATION BETWEEN GENETIC POLYMORPHISMS OF DNA REPAIR GENES (XPC, XPG) AND HEAD AND NECK CANCER SUSCEPTIBILITY IN INDIAN POPULATION: A HOSPITAL BASED CASE-CONTROL STUDY.

Rohit D. Vhaval, Kailas D. Datkhile*, Madhavi N. Patil, Tejasvi S. Khamkar, Pratik P. Durgawale, Satish V. Kakade

ABSTRACT

Background: Smoking and alcohol related head and neck cancer is a major concern of health risk in rural parts of developing countries, such as India. In this study, we aimed to determine the frequency of polymorphisms in DNA repair gene, Xeroderma pigmentosum complementation group C (XPC) and Xeroderma pigmentosum complementation group G (XPG) in patients of oral cancer from western Maharashtra and to evaluate their association with oral cancer development. Methods: We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to analyze XPC & XPG gene polymorphisms in 320 patients with oral cancer and in 400 age and sex matched disease-free controls. Results: The result from our study showed that allele frequencies of selected genes were not statistically different between the groups for XPC Gln939, XPGAsp1104. XPC Intron 11 (OR= 4.65; 95% CI= (3.16-6.85); p= <0.0001) genotypes significantly increased the risk of head and neck cancer. Conclusions: This study indicates that polymorphisms in intron11 of XPC gene could play a role in modifying genetic susceptibility of individual to head and neck cancer in Maharashtra patients. The case-control study suggests that selected DNA repair genes represent genetic determinants in oral carcinogenesis along with other environmental risk factors in the unexplored rural Indian population.

Keywords: Genetic polymorphisms, XPC, XPG, cancer risk, genotyping, PCR-RFLP


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )