EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

ENHANCEMENT OF ANTIBACTERIAL COMPOUNDS PRODUCTION BY ASPERGILLUS FLAVUS AND PENICILLIUM CITRINUM ISOLATED FROM LOCALS FOODS IN BOBO DIOULASSO AND OUAHIGOUYA, BURKINA FASO

Hamidou Compaore*, Hagrétou Sawadogo-Lingani, Filbert Guira, Serge Samandoulougou, Aly Savadogo, Dayéri Dianou and Alfred S. Traore

ABSTRACT

This current study was carried out to optimize media components and culture conditions for maximum antibacterial compound production and extraction by Aspergillus flavus and Penicillium citrinum. A total of five (5) isolates of Aspergillus and six (6) isolates of Penicillium were collected from groundnut and rice. Out of which one of each genera found to be promising. These isolates were identified as Aspergillus flavus and Penicillium citrinum according to respectively Raper and Fennell[1] and Pitt[2] key. The influence of culture conditions including incubation duration, incubation temperature, initial pH, agitation rate and different carbon and nitrogen sources on growth and bioactive compound production was investigated. This production was done by fermentation in synthetic broth: 5 g/l yeast extract, 1 g/l KH2PO4, 0.5 g/l MgSO4.7 H2O, 0.01 g/l FeSO4.7 H2O, 15 g/l NaCl, 30 g/l Glucose during one week in shaker. The disc diffusion method was used to study the antibacterial activities against two (2) Gram negative and two (2) Gram positives bacteria. The antibacterial activity was estimated on the basis of diameter of inhibition zone. Fungi showed high rate of antibacterial compound with yeast as nitrogen sources on the 7-9 days in fermentation at temperature of 30ºC and 150 rpm of the rotary shaker. The best carbon source was starch and glucose for Aspergillus flavus at pH 7 and starch and sucrose at pH 6 for Penicillium citrinum.

Keywords: antibacterial compound, Aspergillus flavus, Penicillium citrinum, Culture media, culture condition, Enhancement.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia