EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

COMPARISON OF INTRAVENOUS PARACETAMOL AS PREEMPTIVE AND PREVENTIVE ANALGESIC IN PATIENTS UNDERGOING PYELOLITHOTOMY: A PROSPECTIVE, RANDOMISED DOUBLE BLIND, COMPARATIVE STUDY

Dr. Indira Kumari, *Dr. Vikas Sharma, Dr. Udita Naithani, Dr. Sandeep Sharma, Dr. Charu Sharma and Dr. Ankush Garg

ABSTRACT

Aim and objectives: Aim of this study is to compare the effects of intravenous paracetamol as: Pre-emptive analgesic and Preventive analgesic as regards to hemodynamics, pain control and duration of analgesia in patients undergoing pyelolithotomy under general anaesthesia. Patients and methods: 60 patients randomised in two groups undergoing pyelolithotomy under general anaesthesia. In Group Pe, intravenous paracetamol, 1 g was administered over 15-20 minutes, 30 minutes prior to induction of anaesthesia as pre-emptive analgesia and 100 ml NS (placebo) was given over 15-20 minutes, 30 minutes prior to completion of surgery. In Group Pv, 100 ml NS (placebo) was given over 15-20 minutes, 30 minutes prior to induction of anaesthesia and intravenous paracetamol, 1 g was administered over 15-20 minutes, 30 minutes prior to completion of surgery as preventive analgesia. Intraoperative vitals, intraoperative fentanyl, postoperative vitals and VAS score was noted and compared. Results: Pre-emptive paracetamol contributed to intraoperative analgesia leading to better control of hemodynamics in intraoperative period and it also provided early postoperative analgesia (around 1.25 hr). Preventive paracetamol is better in terms of providing longer duration of postoperative analgesia (around 4 hr), but it requires additional opioid administration during intraoperative period to supplement analgesia for better hemodynamic stability. Conclusions: In our opinion, iv paracetamol should be better administered pre-emptively, because of its advantage of providing analgesia during intraoperative as well as early postoperative period.

Keywords: Pyelolithotomy, Paracetamol, Pre-emptive analgesic, Preventive analgesic.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia