EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ETHNOPHARMACOLOGICAL APPROACH OF HEDERAGENIN ATED FROM SAPINDUS TRIFOLIATUS L. ON NON ALCOHOLIC FATTY LIVER DISEASE (NAFLD) ASSOCIATED WITH TYPE 2 DIABETES IN C57BL/6 MICE

Vinitha Lakshmi*, Dhamotharan. R, Kalyan kumar. G

ABSTRACT

Ethnopharmacological relevance: Hederagenin, a saponin extracted from fruits of Sapindus trifoliatus is used as astringent, thermogenic, anti-inflammatory, analgesic, antifungal, antiviral, anti helmintic and tonic in action. NAFLD is a liver disorder characterised by fat accumulation and is treated only at the advanced stages of cirhossis. The cure of it still remains untold. Whereas the current approach with traditional medicine has found it successful in reducing the liver enlargement and removes the accumulated fat indicating the right choice of medicine for NAFLD. Aim of the study: The present study investigated the activity of Hederagenin on non alcoholic fatty liver disease (NAFLD) associated with type 2 diabetes in murine model which is a novel approach. Materials and methods: Male C57BL/6 mice (6–8 weeks of age) were fed with high fat diet for eight weeks and then dosed with Hederagenin at doses of 100, 300 and 500 mg/kg p.o., metformin for 350mg/kg p.o. Normal control animals were fed with normal standard pellet diet whereas the positive control group along with treatment group still maintained the high fat diet. At the end of the experimental period, the final body weight and feed intake were taken and whole blood was collected by retro orbital sinus punctures. Plasma/serum was obtained by cold centrifugation (4°C) till analysis. Later animals were sacrificed by cervical dislocation and, liver were excised and stored at - 80°C. Results: Hederagenin significantly suppressed lipid accumulation in the liver, reduced biochemical, insulin resistance, and lipid in HFD-fed C57BL/6 mice. These findings may provide molecular evidence for the use of Hederagenin as a therapy in the management of fatty liver and obesity-relative disorders. Conclusion: These findings may exhibited the use of Hederagenin as a therapy in the management of fatty liver and obesity-relative disorders.

Keywords: NAFLD, NASH, Hederagenin, C57BL/6 mice, HFD fed mice, Type 2 diabetes.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )