EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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 ISSN 2394-3211

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Abstract

PHYTO CHEMICAL SCREENING AND ANTI DIABETIC ACTIVITY OF MOMORDICA CHARNTIA FRUIT EXTRACT

Kinara M.* Iswar Hazarika, Mareena John, Ansu Methew, Vineeth Chandy and Anju Das

ABSTRACT

Research aims to investigate the phytoconstitutes and antidiabetic activity of Momordica charntia. (Family: Cucurbitaceae) fruit extracts in alloxan induced diabetic albino rats. A comparison was made between the action of Momordica charntia extracts and a known antidiabetic drug glibenclamide (600 μg/kg body wt.). An oral glucose tolerance test (OGTT) was also performed in experimental diabetic rats. The petroleum ether, chloroform, methanolic extracts of Momordica charntia were obtaine by soxhlet extraction method and subjected to standardization by following pharmacognostical and phytochemical screening methods. Dose selection was made on the basis of acute oral toxicity study in mice (50mg to 5000 mg/kg body weight) as per OECD guidelines. Momordica charntia chloroform extract and methanolic extract showed significant (P<0.01) antidiabetic activity. In alloxan induced model, blood glucose level of these extracts on the seventh day of study were (ME:96.33±9.75) and (CE: 83.33±6.62) in comparison of diabetic control (224.50±4.72). In OGGT model (glucose loaded rats), exhibited glucose level after 30 min. for ME (127.66±3.21) and 90 min. (99.66±4.79) whereas after 30 min. for CE (122.33±3.32) and 90 min. (96.12±3.25). These extracts also prevented body weight loss in diabetic rats. The anti hyperglycemic action of the extracts may be due to improving the glycemic control mechanisms. The drug has the potential to act as antidiabetic drug.

Keywords: Momordica charntia; Diabetes mellitus; Alloxan monohydrate; Oral glucose tolerance test.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia