A COMPARATIVE STUDY OF THE EFFICACY OF 5% AMLEXANOX IN THE MANAGEMENT OF RECURRENT MINOR APHTHOUS ULCERS
Dr. Jatin Gupta and *Dr. Kanupriya Gupta
Background: Recurrent minor aphthous ulcer (RAU) is a common oral disorder which is multifactorial in origin and difficult to treat. Goals of treating aphthous ulcers include; accelerating the healing of ulcers, pain relief and prevention of recurrences. Aim and Objective: The aim of this study was to study the efficacy of 5% Amlexanox paste in treatment of Recurrent minor aphthous ulceration (RAU) and compare the results with those of 2% Lignocaine anesthetic gel. Materials & Methods: 60 patients with diagnosis of minor recurrent aphthous ulcers were included in this clinical study. The individuals were randomly divided into Group 1 (5% Amlexanox oral paste) and Group 2 (2% Lignocaine gel). The number, size, erythema and pain level of ulcers were measured and recorded on treatment days 1st, 3rd and 6th. Finally, the results were compared using student unpaired t test. Results: On comparison between the two groups significant difference was observed on 6th day in reduction of number of ulcers. Amlexanox oral paste significantly reduced ulcer size and erythema (p≤0.05 for day 3 and day 6). 2% Lignocaine gel was less beneficial in reducing ulcer size and erythema. When overall comparison of the VAS was made, the study group had lower pain scores than the control group on 6th day. (P value < 0.05, statistically significant). Conclusion: Amlexanox oral paste is as effective and safe in the treatment of apthous ulcers. It can reduce the frequency, duration and symptoms associated with the disease with no side-effects attributed to the drug.
Keywords: Recurrent apthous ulcer, 5% Amlexenox paste, 2% Lignocaine gel.
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