EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

A COMPARATIVE STUDY OF THE EFFICACY OF 5% AMLEXANOX IN THE MANAGEMENT OF RECURRENT MINOR APHTHOUS ULCERS

Dr. Jatin Gupta and *Dr. Kanupriya Gupta

ABSTRACT

Background: Recurrent minor aphthous ulcer (RAU) is a common oral disorder which is multifactorial in origin and difficult to treat. Goals of treating aphthous ulcers include; accelerating the healing of ulcers, pain relief and prevention of recurrences. Aim and Objective: The aim of this study was to study the efficacy of 5% Amlexanox paste in treatment of Recurrent minor aphthous ulceration (RAU) and compare the results with those of 2% Lignocaine anesthetic gel. Materials & Methods: 60 patients with diagnosis of minor recurrent aphthous ulcers were included in this clinical study. The individuals were randomly divided into Group 1 (5% Amlexanox oral paste) and Group 2 (2% Lignocaine gel). The number, size, erythema and pain level of ulcers were measured and recorded on treatment days 1st, 3rd and 6th. Finally, the results were compared using student unpaired t test. Results: On comparison between the two groups significant difference was observed on 6th day in reduction of number of ulcers. Amlexanox oral paste significantly reduced ulcer size and erythema (p≤0.05 for day 3 and day 6). 2% Lignocaine gel was less beneficial in reducing ulcer size and erythema. When overall comparison of the VAS was made, the study group had lower pain scores than the control group on 6th day. (P value < 0.05, statistically significant). Conclusion: Amlexanox oral paste is as effective and safe in the treatment of apthous ulcers. It can reduce the frequency, duration and symptoms associated with the disease with no side-effects attributed to the drug.

Keywords: Recurrent apthous ulcer, 5% Amlexenox paste, 2% Lignocaine gel.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia