EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

AMELIORATIVE EFFECT OF ACONITUM HETEROPHYLLUM (WALL EX ROYLE) ON, ERYTHROCYTE ANTIOXIDANTS AND LIPID PEROXIDATION IN STZ- INDUCED DIABETIC RATS

Tanveer Ahmad Rah, S. Hemalatha*, C. Elanchezhiyan and G. Archunan

ABSTRACT

The present study was carried out to evaluate the beneficial effects of Aconitum heterophyllum (AH) on altered erythrocyte lipid peroxides and antioxidants in streptozotocin induced diabetic rats. Diabetes mellitus was induced in adult male albino wistar rats by a single intraperitoneal injection of streptozotocin (40 mg/kg of body weight). The streptozotocin induced diabetic rats were treated with Aconitum heterophyllum extract 200 mg/kg b.w for 28 days. The enzymatic superoxide dismutase (SOD), Catalase (CAT) and glutathione peroxidase (Gpx) and non-enzymatic antioxidants Vitamin C, Vitamin E and Reduced Glutathione antioxidant activity significantly decreased and simultaneously lipid peroxidation markers like thiobarbituric acid reactive substances (TBARS) and hydroperoxides (LOOH) significantly was increased in erythrocytes of diabetic rats. Administration of Aconitum heterophyllum (200mg/kg bw) and glibenclamide reverted these parameters towards normalcy when compared with untreated diabetic rats. From the present study, it is evident that, Aconitum heterophyllum extract possesses significant, antioxidant and antilipidperoxidation properties without any toxic effects.

Keywords: Erythrocytes, Aconitum heterophyllum, antioxidants.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia