EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

“EFFICACY AND SAFETY OF MEPHENTERMINE, EPHEDRINE AND PHENYLEPHRINE ON POST SUBARACHNOID BLOCK INDUCED HYPOTENSION DURING LOWER SEGMENT CAESAREAN SECTION (LSCS): A RANDOMIZED, DOUBLE BLIND, PARALLEL GROUP CLINICAL TRIAL.”

H. N. Golakiya, J. B. Patel*, V. N. Naik, K. D. Nakum, D. C. Tripathi and C. B. Tripathi

ABSTRACT

Background: Lower segment caesarean section (LSCS) is commonly performed operation under subarachnoid block (SAB). Post SAB hypotension is the most common complication requiring variable doses of vasopressors to prevent detrimental consequences of hypotension to mother and fetus. Methods: This randomized, double blind, parallel group clinical trial included a total of 150 parturients undergoing emergency or elective LSCS. We compared the effect of mephentermine, ephedrine and phenylephrine immediately after the SAB. Parturients in the, mephentermine and ephedrine group received 10 mg intravenous bolus and 5 mg i.v. for maintenance; phenylephrine group received 100 μg i.v. bolus and 50 μg i.v. for maintenance. Maternal systolic and diastolic blood pressure, heart rate, fetal APGAR score, number of doses required were recorded for 3 hrs. Any episodes of adverse events were recorded. Results: We observed less changes in SBP with phenylephrine (mean diff. from baseline- MDB: 3.8 – 7.26) than mephentermine (MDB: 7.34 – 9.56) and ephedrine (MDB: 8.9 – 12.88) for initial 6 min only. We observed less changes in DBP with phenylephrine (MDB: 1.6 – 7.64) than mephentermine (MDB: 5.86 – 11.5) and ephedrine (MDB: 5.42 – 11.12) for initial 6 min only. HR decreases more significantly with phenylephrine compared to mephentermine and ephedrine (P< 0.05). Bradycardia, headache, nausea, reactionary hypertension (12%) were the side effects with phenylephrine. Conclusion: There is no clinically significant difference among mephentermine, ephedrine and phenylephrine immediately after the SAB. There was a trend for less requirement of maintenance dose with ephedrine. Phenylephrine causes fall in HR which may be advantageous in cardiac patients and in whom tachycardia is undesirable.

Keywords: Subarachnoid block, mephentermine, ephedrine, phenylephrine, hypotension, LSCS.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia