SCREENING OF DAMASK ROSE ESSENTIAL OIL IN WISTAR ALBINO RATS FOR ANTIULCER ACTIVITY

*B. Suhasini and Nasreen Sulthana

ABSTRACT

Introduction: Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 5-10% of population in their life time. In recent years; abundant work has been carried out on herbal medicine to clarify their potential efficacy in gastric ulcer prevention or management. Objectives: The present study was carried out to investigate antiulcer activity of Rosa damascena mill belonging to family Rosaceae in the albino rats. Methods: Pyloric ligation and alcohol induced ulceration methods were used. Ranitidine (20mg/kg) was used as the standard drug. Rose oil was preliminary subjected to the acute oral toxicity study according to OECD guidelines no: 423 based on which, two dose levels i.e. 250 and 500 mg/kg were selected for the further study. In pylorus ligation induced ulcer model, various parameters were studied viz. gastric volume, total acidity, free acidity and ulcer index. Ulcer index and percentage inhibition of ulceration were determined by alcohol induced ulcer model. Results: Rose oil at 500mg/kg shown 68.36% inhibition in alcohol induced ulcer model and 56.5 % in pyloric ligation induced ulcer model. Conclusions In conclusion, rose oil tested in this investigation deserves further attention due to its importance in prevention and treatment of gastric ulcers. Further molecular level studies are to be done for knowing its exact mechanism of action.

Keywords: Rosa damascene, Ulceration, Ligation, Phytochemicals.