EXPLORING STRUCTURAL FEATURE OF BENZOTIAZOLE DERIVATIVES EMPLOYING FUJITA–BAN AND HANSCH APPROACH
Rizwan Khan* and Dr. Love Kumar Soni
Designing of active compounds of benztriazole derivatives which are highly selective, potent and safe inhibitor of
CYP51 enzyme for inhibition of ergosterol pathways for maximum antifungal activity has been done. In our study,
we did quantitative structure–activity relationship (QSAR) analysis, based on Fujita–Ban and classical Hansch
approach, on benzotriazole derivatives. First, the Fujita-Ban approach has been followed, which revealed the
highest activity contribution for the 5- substituted benztriazole derivatives with bulkier group is supported.
Further, the Hansch approach confirms that 5- substituted benztriazole derivatives with bulkier group are active.
The hydrophobic properties of the various substituent have been found to play major roles in the binding of these
compounds with the receptor.
Keywords: Antifungal, Benzotriazole derivatives, Fujita Ben Analysis, QSAR relationship.
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