FORMULATION AND EVALUATION OF FLOATING MATRIX TABLETS OF CEFPODOXIME PROXETIL

N. Swati*, Ayesha Farhath Fatima, Dr. Sobia Noor, Dr. Pathan Amanulla khan and Azmath Fathima

ABSTRACT

In this study, we design and evaluated floating matrix tablets of Cefpodoxime Proxetil, to prolong gastric residence time and increase drug absorption further increasing the bioavailability. Preformulation studies were carried out to optimize the required quantity for HPMC (K4M). (K15M). (K100M). Total 12 formulations were prepared. Fourier transform Infrared spectroscopy confirmed the absence of any drug/polymers/excipients interactions. The tablets were prepared by direct compression technique, using polymer such as hydroxy propyl methyl cellulose HPMC (K4M). (K15M). (K100M) with other standard excipients like sodium bicarbonate, MCC and Magnesium stearate used as gas generating agent, as filler and as lubricant respectively. Tablets were evaluated for physical characterization. All the matrix tablets showed significantly greater swelling index and exhibited controlled and prolonged drug release profiles and some floated over the dissolution medium for more than12 hr. The optimized showed no significant change in physical appearance, drug content, floatability or in-vitro dissolution pattern after storage at 45oC at 75% RH for three months.

Keywords: Cefpodoxime Proxetil, swelling index, floating capacity, HPMC.