HALOPERIDOL LEADS TO TORSE DE POINTES IN SCHIZOPHRENIC POOL

Awais Ali Zaidi, Lubna Shakir, Tanveer Ahmed Khan*, Mahtab Ahmad Khan, Arsalan Ali, Atta Ur Rehman

ABSTRACT

Schizophrenia is a mental disorder characterized by diminishing of emotions, intelligence, social isolation, speech confusion, behavioral misconceptions and hallucinations. Intravenous (IV) haloperidol is effective and safe for the tranquility of the patients to be freed from numerous hazardous circulatory & anticholinergic side effects of the anti-schizophrenics drugs. In patients with schizophrenia, haloperidol is better choice than atypical schizophrenic drugs for improvement in symptoms but increases the rates of parkinson’s disease, akathisia, and acute dystonias substantially. The dose dependent side effects like hyperlipidemia and torese de point (prolongation of QT interval) are the worst side effect of haloperidol, which is the major cause of death in schizophrenic patients. Typical anti-schizophrenic drugs are as potent as atypical schizophrenic drugs and if used in proper dosage as recommended by physicians’ patients can live a progressive life. Furthermore, there should be provision of healthy environment to schizophrenic patients, so they become helpful to society.

Keywords: Haloperidol, Schizophrenia, QT interval, Hyperlipidemia, Torese de point.