EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PREVALENCE AND ROLE OF ISABA1 ASSOCIATED WITH BLAOXA-51 AND BLAOXA-23 GENES IN CARBAPENEM-RESISTANT ACINETOBACTER BAUMANNII

Kais Kassim Ghaima*

ABSTRACT

The global spread carbapenem-resistant Acinetobacter baumannii has become a serious problem especially in burn units. The purpose of this study was to detect the association of blaOXA-51 and blaOXA-23 carbapenmase genes with ISAba1 and their effect on carbapenem resistance. To detect insertion sequences ISAba1/blaOXA-23 and ISAba1/blaOXA-51, mapping by PCR using combinations of forward primers ISAba1 and reverse primers of blaOXA-23 and blaOXA-51 were used. A total of 96 isolates of A. baumannii were obtained from burns and wounds infections from Baghdad hospitals, Iraq. Antibiotic sensitivity patterns showed that 70.8% (n=68) of the isolates were resistant to Imipenem and Meropenem, while 13 isolates were susceptible to both antibiotics (13.5%). Of 68 isolates resistant to Imipenem and Meropenem, ISAba1 was detected in 61 isolates (89.7%). 50 isolates carried blaOXA-23 gene, all contained ISAba1 upstream of blaOXA-23 gene, and 41 contained ISAba1 upstream of blaOXA-51 gene. ISAba1 was found upstream of blaOXA-23 only in isolates resistant to carbapenems. Both susceptible and resistant isolates had ISAba1 upstream of blaOXA-51. The ISAba1-activated blaOXA-23 genes were prevalent among the carbapenem-resistant A. baumannii isolates in our hospitals and carbapenems resistance may be due mainly to ISAba1 upstream of blaOXA-23 gene. The present study revealed that the presence of ISAba1/blaOXA-51 in A.baumannii isolates was not contributing in the carbapenems resistance.

Keywords: Acinetobacter baumannii, ISAba1, carbapenems resistance.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )