EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

HORMONAL PROFILE IN EARLY MENOPAUSE

Eltayeb Tayrab*, Rasha Musa and Zeinab Abdalla

ABSTRACT

Early cessation of the cycle in the reproductive age is harsh for women. The aim of this study was to evaluate the hormonal profile in infertile Sudanese women complaining of premenopausal amenorrhea, including serum luteinizing hormone (LH), follicle stimulating hormone (FSH), thyroid stimulating hormone (TSH), prolactin and estradiol (E2). This case control- cross sectional study was done in the 5 clinics of infertility in tertiary care hospitals in Khartoum-Sudan, from: May 2012 to December 2014. The study included 323 infertile premenopausal amenorrheic women and 198 ages matched women with proven fertility as control. ELISA method was used to measure serum levels of FSH, LH, TSH, prolactin and E2. Data was analyzed by IBM, SPSS version 20. The mean of the prolactin in the amenorrheic women was (121.5±1 265.12)ng/ml versus (15.09± 6.07)ng/ml in the control group; with P. value (0.000), FSH (50.33 ± 34.04) IU/ml versus (8.71 ± 31.29) IU/ml; with P.value (0.000), LH (34.89± 22.71) IU/ml versus (6.27± 2.55) IU/ml; with P.value (0.000), TSH (1.75± 2.02)IU/ml) versus (1.27± 0.76) IU/ml; with P.value (0.004) and E2 (40.16± 34.30)pg/ml versus (50.68± 16.74)pg/ml ;with P value (0.029). The prevalence of secondary amenorrhea among the study group was 315 (97.5%). In premenopausal amenorrheic Sudanese; secondary amenorrheic is most common. Serum prolactin, FSH, LH, and TSH significantly increase; while estradiol significantly decreases.

Keywords: Premenopause, amenorrhea, hormones, serum, Sudan.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia