FORMULATION AND EVALUATION OF ETHOSOMAL GEL CONTAINING CLOBETASOL.

Sushant Korade*, Prof. Deshmukh M. T., Dr. R. V. Shete

ABSTRACT

The present study involves formulation and characterization of ethosomal gel containing Clobetasol propionate used to treat dermatitis anti psoriasis. The transdermal delivery is one of the most important routes of drug administration. The main factor which limits the application of transdermal route for drug delivery is the permeation of drugs through the skin. One simple and convenient approach is application of drugs in formulation with elastic vesicles or skin enhancers. significant enhanced delivery of Clobetasol propionate through transdermal route could be obtained by using vesicular drug carrier systems - Ethosomes. The current study was aimed to investigate the potential of ethosomes in enhancement of clobetasol transport across the skin, characteristics of ethosomes and their in-vitro skin permeation behaviour. The present work also focuses on making the formulation more pharmaceutically acceptable. In this study, the drug and the polymer interaction studies were performed by using FTIR Spectroscopy for its unknown compatibility.

Keywords: Ethosomal gel, clobetasol, psoriasis.