FABRICATION AND IN VITRO EVALUATION OF LIPOSOME CONTAINING QUERCETIN

Shati Ghosh, Sudipta Das*, Arnab Samanta

ABSTRACT

The present work was focused on the preparation and in vitro release kinetics of liposomal formulation of quercetin, which was prepared by thin film hydration method. Three batches of liposomes were prepared using varying weight ratio of L-α-phosphatidylcholine and cholesterol. Drug entrapment, in vitro drug release, drug release kinetics, and stability studies were used to evaluate the prepared liposomal formulation of quercetin. The in vitro release of drug across dialysis membrane reveals slowest rate of drug release from F3 formulation and the fastest release from F1 batch in 4 hours. F1 batch was packed in Eppendorf tube and stored at 4° C temperature for one month. In comparison to other batches, the F1 batch demonstrated the most promising results. The stability studies of the final batch (F1) for one month showed no significant changes.

Keywords: Liposome, Quercetin, Cholesterol, Lecithin, Drug release.