EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

ENDOSULFAN INDUCED OXIDATIVE STRESS AND BIOCHEMICAL CHANGES IN TESTES OF MICE

A. Nath, Aseem Kumar Anshu*, Priyanka, Chandan Kumar Singh, Sachidananda Behera, J. K. Singh

ABSTRACT

Endosulfan is potent toxicogen and carcinogen. It is widely used in agriculture and detected in soil, surface water, and underground water, fruits, vegetables and milk. A number of studies have been performed to investigate the effect of endosulfan on reproductive system. Exposure to endosulfan leads to degeneration of spermatogenesis, lower testosterone level and induce oxidative stress. Swisss albino male mice were grouped as control and endosulfan treated for 4, 8, 12 weeks at animal house of S S Hospital and Research Institute, Patna. Sperm count was performed by routine process, testosterone level was determined by ELISA kit method, and lipid peroxidation was done by measuring MDA level in blood serum. Decrease in testicular weight, sperm count, testosterone level and increase in MDA level were observed when compared with control upon administration of endosulfan at the rate of 3 mg/kg/body weight with significance of (p-value<0.0001). The effect of endosufan on reproductive system is deleterious and insidious. Endosulfan has been used in agriculture widely and enters human body system through food chain to cause toxicity. Hence more studies and investigations are warranted in this field to land to unravel the mechanism by which endosulfan impairs the reproductive system.

Keywords: Endosulfan, toxicogen, carcinogen.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia