EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

LITHIUM AND SODIUM VALPROATE COMBINATION THERAPY VERSUS MONOTHERAPY IN TREATMENT OF BIPOLAR DISORDERS: AN OBSERVATIONAL COHORT STUDY

Dr. Neeli Uma Jyothi, Mounica. Bollu*, Sk. Faizan Ali, D. Sri Chaitanya and M. Chiranjeevi

ABSTRACT

Background: Bipolar disorder is one of the lifelong psychiatric illness affecting the population. Lithium and sodium valproate are each recommended as a monotherapy for preventing relapses in patients with bipolar disorders and are sometimes used in combination. However combination and monotherapy have never been compared rigorously. Aim: To compare the effectiveness of combination therapy of lithium and sodium valproate with the monotherapy in the treatment of bipolar disorders in the clinical practice. Methods: An observational cohort study was performed in the psychiatric hospital settings among the individuals who were diagnosed with BPAD and randomly allocated to 3 groups among which one group received the lithium alone and another group received sodium valproate monotherapy and a third group with a combination of lithium and sodium valproate during the period from jan 2015 to march 2015. Results: A total of 75 participants were included in the study,among which 25 received the lithium monotherapy and 25 received the sodium valproate monotherapy .combination of lithium and sodium valproate was given to 25 patients.from the study ,it was found that the reduction in the symptoms and better prognosis was observed among the participants who received the combination therapy. Conclusion: In daily clinical practice ,treatment with combination of lithium and sodium valproate was found to be superior to individual monotherapy.

Keywords: Bipolar Disorder, Lithium, Sodium Valproate, Treatment.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )