A RESEARCH ON: FORMULATION, DEVELOPMENT AND EVALUATION OF BEETROOT NANOVESICLE GEL FOR ENHANCED ANTIOXIDANT ACTIVITY AND SKIN PERMEATION

Ajay Sunil Thorat*, Kalyani Jaywant Bhor, Payal Dnyaneshwar Nannaware, Soham Sandeep Lokare, Sharad Balu Narhe

ABSTRACT

The present research focuses on the formulation, development, and evaluation of a beetroot (Beta vulgaris) based nanovesicle gel designed for enhanced antioxidant activity and improved skin permeation. Beetroot is a rich natural source of betalains, flavonoids, phenolic compounds, and other bioactive molecules exhibiting strong antioxidant potential. However, their poor stability and limited skin penetration restrict topical application. To overcome these limitations, nanovesicular drug delivery systems were developed to enhance the stability, bioavailability, and dermal penetration of beetroot phytoconstituents. The nanovesicles were incorporated into a gel base to improve patient compliance, spreadability, and controlled release properties. The formulated nanovesicle gel was evaluated for physicochemical properties, pH, viscosity, homogeneity, spreadability, in vitro drug release, and antioxidant activity using standard assays such as DPPH. The study demonstrates that nanovesicle-based gel significantly enhances antioxidant activity and skin permeation compared to conventional formulations, making it a promising approach for herbal dermatological applications.[1] Beetroot extract was incorporated into nanovesicles prepared using suitable phospholipids and incorporated into a gel base containing selected excipients. The developed formulation was evaluated for various physicochemical and performance parameters including appearance, colour, odour, homogeneity, pH, viscosity, spreadability, and stability. Antioxidant activity of the formulation was assessed using suitable radical scavenging methods such as DPPH and ABTS assays, while skin permeation characteristics were evaluated using appropriate diffusion studies.

Keywords: Beetroot, Nanovesicles, Herbal Gel, Antioxidant Activity, Skin Permeation, Phytosomes, Drug Delivery System, Betalains.