EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

SHORT SEQUENCE RNAS AND LIPID CONJUGATES AS NOVEL DRUG DELIVERY SYSTEMS

Manoj G. Tyagi*, William T. Raja and Kapil D. Sagar

ABSTRACT

Lipids are an integral part of the cell membrane and synthetic lipids have become increasingly important as
formulation excipients and as active ingredients per se. The present article summarizes particular features of
commonly used phospholipids and their application spectrum and elucidates current strategies to improve
bioavailability and disposition of administered microRNA or short interfering RNA (miRNA)/siRNA).
Technological strategies to achieve these effects are highly diverse and offer various possibilities of liquid, semiliquid
and solid lipid based formulations for novel nucleotide based delivery optimization. The complexity of
microRNA-mediated pathway control has burgeoned since the discovery that miRNAs are found in the
extracellular space and constitute a form of cell to cell communication. miRNAs have been found in plasma, urine,
and saliva and have recently been shown to be carried on lipoproteins. Although our understanding of the cellular
machinery responsible for the secretion of miRNA is still incomplete, there is little doubt that extracellular
miRNAs delivered as conjugates with lipids will hold tremendous potential as both diagnostic and therapeutic
agents.

Keywords: Nanoparticles, phospholipids, microRNA, drug, membrane.


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  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 April 2024 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia