COPPER – QUINOLINE COMPLEXES AS BIOACTIVE AGENTS: A REVIEW

Vibha Chaudhary*, Priyanka Swami, Aman Bishnoi, Mohammed Bilal, Narendar Bhojak

ABSTRACT

Quinoline and its derivatives are important heterocyclic moieties widely used in the evolution of biologically active drugs because of their versatile applications. In past few years use of metal complexes of Quinoline has been continuously increasing. Metal complexation can improve drug stability, bioavailability and target specificity also introducing novel mechanisms of action. Through recent research it has been observed that copper complexes are potentially important as medicinal agents. The quinoline scaffold and its copper metal derivatives show high efficiency of biological activities, making them ideal for novel multifunctional therapeutic agents. This review focus on the extensive studies of quinoline based copper coordination compound emphasizing on their comparative biological evaluation. In this review work we highlighted the role of copper complexes as antibacterial, antifungal, anticancer, DNA cleavage and DNA binding agents.

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