ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF MARKETED LIQUID BANDAGE SPRAY USING UV SPECTROSCOPY

*Miss. Dhanshri Subhash Jadhav, Dr. Sagar E. Tambe., Miss. Asmita A. Hulawale

ABSTRACT

The present study focuses on the development and validation of a simple, economical, and reliable UV spectroscopic method for the analysis of marketed liquid bandage spray formulation. Topical spray formulations are increasingly preferred because of their ease of application, rapid drying property, and ability to provide localized therapeutic action. Accurate analytical evaluation of such formulations is essential to ensure quality, efficacy, and safety during pharmaceutical manufacturing and routine quality control. The calibration curve demonstrated good linearity with correlation coefficient close to 0.999, confirming adherence to Beer-Lambert’s law. The developed method was validated according to ICH guidelines for parameters including linearity, accuracy, precision, robustness, limit of detection (LOD), and limit of quantification (LOQ). The percentage recovery values were found within acceptable limits, indicating accuracy of the developed method. Precision studies showed low %RSD values, confirming reproducibility of the analytical procedure. The developed UV spectroscopic method was found to be simple, rapid, cost-effective, and suitable for routine pharmaceutical quality control analysis of marketed liquid bandage spray formulations. The method can also be applied in academic laboratories and industrial analytical studies for quantitative estimation of topical pharmaceutical preparations.

Keywords: UV spectroscopy, liquid bandage spray, analytical method development, validation, calibration curve, pharmaceutical analysis.