FOMULATION AND EVALUATON OF IMMEDIATE RELEASE TABLETS OF HIBISCUS ROSA –SINENSIS AND ACMELLA OLERACEA FOR DIURETIC ACTIVITY

Moikar Snehal Vishwanath*, Khaladkar Shraddha Madan

ABSTRACT

The present study focuses on the formulation and evaluation of immediate release tablets containing extracts of Hibiscus rosa-sinensis and Acmella oleracea for assessing diuretic activity. Herbal extracts were selected based on their reported pharmacological potential, particularly the diuretic effect of Hibiscus rosa-sinensis, which has been shown to significantly increase urine output and electrolyte excretion in experimental models , and the diverse therapeutic properties of Acmella oleracea, including bioactive phytoconstituents with potential renal and systemic effects.Innovare Academics Journals. The prepared tablets were evaluated for physicochemical parameters including weight variation, hardness, friability, thickness, and disintegration time, ensuring compliance with pharmacopeial standards. In vitro dissolution studies confirmed rapid release of active constituents, indicating suitability of the formulation for immediate therapeutic action.The diuretic activity of the formulated tablets was evaluated using standard experimental models (e.g., Lipschitz test) by measuring urine volume and electrolyte excretion (Na⁺, K⁺, Cl⁻) in treated groups compared to control and standard diuretics. The formulation exhibited significant, dose-dependent enhancement in urine output and electrolyte excretion, demonstrating comparable efficacy to standard drugs.

Keywords: Immediate release tablets, Herbal formulation, Diuretic activity,Polyherbal tablets,Tablet formulation.