POLYHERBAL WOUND HEALING FORMULATIONS INCORPORATING AEGLE MARMELOS AND CALOTROPIS PROCERA: AN EVIDENCE-BASED REVIEW

Shruti Arun Kshirsagar*, Aishwarya J. Jadhav

ABSTRACT

Maintaining the continuity and protective function of skin is vital to overall human health, and any breach in this continuity demands an efficient reparative response. Traditional plant-derived medicines have gained renewed scientific interest as potential wound healing agents because of their multifaceted pharmacological properties, relative safety, and accessibility. The present review explores the therapeutic utility of two well-documented medicinal plants — Aegle marmelos (Bael) and Calotropis procera (Madar) — in the context of polyherbal wound healing formulation development. Both plants have been extensively used in Ayurvedic, Siddha, and Unani systems of medicine and carry a rich legacy of application in skin-related disorders. This article provides a systematic account of wound classification schemes, the sequential biological events underlying tissue repair, the botanical and pharmacognostic profiles of the two selected species, the phytochemical basis of their wound healing activity, and the emerging role of modern localized drug delivery systems in optimizing therapeutic outcomes. The significance of key endogenous growth factors in mediating the repair cascade is also addressed. Collectively, the available scientific data suggest that a synergistic polyherbal combination of these two botanicals holds considerable promise for the development of safe, effective, and affordable wound care formulations, warranting formal preclinical and clinical validation.

Keywords: Aegle marmelos, Calotropis procera, wound healing, polyherbal formulation, drug delivery systems, phytochemicals, tissue regeneration, Ayurveda.