EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITIES OF HALLEA STIPULOSA STEM BARK AQUEOUS EXTRACT ON DEXAMETHASONE INDUCED INSULIN RESISTANCE IN RATS.

Poualeu Kamani S. L.*, Wansi S. L., Miaffo D., Tchoumba T. L., Nkeng-Efouet A. P., Kamanyi A.

ABSTRACT

The aim of this study was to examine the hypoglycemic and hypolipidemic activities of aqueous extract of Hallea stipulosa on dexamethasone induced insulin resistance in rats, and to evaluate in vitro the inhibitory activity of this plant extract on α- glucosidase enzyme. Insulin resistance was induced by subcutaneous injection of dexamethasone (1 mg/kg) for 10 days, one hour before administration of different treatments. Body weight and blood glucose level were measured on day 1, 5 and 10. At the end of treatment, glucose tolerance test was performed to the rats, blood samples were collected for triglyceride, total cholesterol, LDL-c and HDL-c level determination. Organs (heart, liver pancreas and kidney) were also collected for relative organ weight determination. The results showed a significant increase (p < 0.001) in serum triglyceride, total cholesterol, LDL-c, blood glucose level, liver weight and a significant decrease (p < 0.001) in HDL-c and body weight observed in dexamethasone control group compared to normal control group. Hallea stipulosa at doses 25, 50 and 100 mg/kg significantly reversed the alteration induced by dexamethasone. Hallea stipulosa significantly reduced postprandial glucose and showed appreciable α-glucosidase inhibitory effect in a concentration-dependant manner (IC50=13.14). These results suggest that Hallea stipulosa stem bark aqueous extract may be useful for the treatment of type 2 diabetes mellitus.

Keywords: Hallea stipulosa, dexamethasone, ?-glucosidase, rats.


[Full Text Article] [Download Certificate]

Citation

  All Since 2019
 Citation  3086  2560
 h-index  18  17
 i10-index  64  44

INDEXING

NEWS & UPDATION

  • EJPMR New Impact Factor

    EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

  • EJPMR: FEBRUARY ISSUE PUBLISHED

    FEBRUARY 2024 issue has been successfully launched on 1 FEBRUARY 2024.

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 February 2024 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia