OPTIMIZATION OF MATRIX TABLETS CONTAINING ALFUZOSIN HCL EMPLOYING HPMC K4 M

B. Srinivasa Rao*, Prof. J. Vijayanratna, Ch. Taraka Ramarao

ABSTRACT

The present investigation involves HPMC K4M was gastro retentive drug delivery systems of alfuzosin HCl using HPMC K4M is the matrixing agent and floating enhancer. The Sodium bicarbonate in the acidic environment reacts with the acid and produces carbon dioxide. The gastro retentive tablets can be formulated to increase the gastric residence time and there by increase the oral bioavailability. From the drug release study it was concluded that the AFTA5 formula of HPMC K4 M matrix tablets have given the controlled release up to 12 hours by showing increased release with floating lag time 29 seconds. Non – Fickian diffusion was the drug release mechanism from the matrix tablets formulated employing HPMC K4 M. The matrix tablets (AFTA5) formulated employing 50 % HPMC K4 M are best suited to be used for gastro retentive dosage form of Alfuzosin HCl. Finally, it can be concluded that good candidates for the preparation of gastro retentive dosage forms due its gastric stability, gastric absorption, less bioavailability.

Keywords: Floating, Lag time, HPMC K4 M, Sodium bi carbonate, GFDDS.