ADVANCES IN TOPICAL DELIVERY STRATEGIES FOR NONSTEROIDAL ANTI-INFLAMMATORY DRUGS: FOCUS ON LIPID-BASED AND GEL-BASED SYSTEMS

Mr. Ritesh Rajesh Bhosale*, Mr. Swapnil S. Patil, Miss. Rutuja Shah, Mr. Sangram Bhogam, Mr. Prashant Dhokare, Mr. Akshy Mane

ABSTRACT

Topical delivery of nonsteroidal anti-inflammatory drugs (NSAIDs) has gained significant attention for the management of localized inflammatory conditions due to its ability to provide site-specific action with reduced systemic exposure. However, conventional topical formulations often exhibit limitations such as inadequate drug permeation, poor solubility, and insufficient retention at the site of application. Recent advancements in formulation approaches have focused on lipid-based systems, including microemulsions and nanoemulsions, as well as gel-based carriers, to overcome these challenges. Lipid-based systems enhance drug solubilization and improve penetration through the skin barrier, while gel systems provide desirable rheological properties and prolonged residence time. The combination of these systems has shown improved performance in terms of drug release and permeation. This review discusses the role of these advanced systems in topical NSAID delivery, highlighting their advantages, formulation considerations, and current challenges, with an emphasis on developing effective and patient-friendly delivery systems.

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