FORMULATION STRATEGIES AS AN APPROACH FOR DISSOLUTION ENHANCEMENT OF OFLOXACIN TABLETS: RECENT ADVANCES AND EVALUATION TECHNIQUES

Sejal Madrecha*, Dr. R. P. S. Rathore

ABSTRACT

Dissolution is a critical factor influencing the performance of oral drug delivery systems, as it governs drug release and absorption. Variations in dissolution behavior may lead to inconsistent therapeutic outcomes. Ofloxacin, a widely used fluoroquinolone antibiotic, requires appropriate formulation design to ensure efficient drug release. Formulation strategies provide an effective approach to improve dissolution performance without altering the chemical nature of the drug. In these approaches, suitable excipients are incorporated to enhance wettability, promote rapid disintegration, and facilitate drug release. Optimization of formulation variables and processing conditions plays an important role in achieving desired tablet characteristics and release profiles. Standard evaluation methods, including preformulation studies and in-vitro dissolution testing, are used to assess formulation performance. Overall, the study highlights the importance of formulation strategies in improving dissolution behavior and drug release characteristics of Ofloxacin, leading to better performance of oral dosage forms.

Keywords: Ofloxacin, Dissolution enhancement, Formulation strategies, Drug release behavior, Superdisintegrants, Tablet formulation, Bioavailability improvement.