REVIEW ON PULSATILE DRUG DELIVERY SYSTEM

*Prof. Abhishek Subhash Narwade, S. Nilesh Vishnu Rasal, S. Yash Sanjay Balkhande, S. Khushal Bhikamchand Kantale, S. Gopal Purushottam Khandagale, S. Prajwal Nilkanth Chandanngole, Dr. Nandu Kayande

ABSTRACT

Pulsatile drug delivery systems (PDDS) are advanced pharmaceutical formulations designed to release drugs in a
time-controlled manner, characterized by a distinct lag phase followed by rapid drug release. Unlike conventional
sustained-release systems, PDDS are developed to synchronize drug availability with the body’s biological
rhythms, an approach closely associated with Chronopharmacology. This targeted delivery is particularly beneficial
in managing diseases that exhibit circadian variation in symptoms and severity.The design of pulsatile systems
involves various strategies, including time-dependent coatings, stimuli-responsive mechanisms, and externally
regulated devices. These systems can be triggered by physiological factors such as pH, enzymes, or temperature,
ensuring site-specific and timely drug release. PDDS have shown significant therapeutic advantages in conditions
like Asthma, Hypertension, and Rheumatoid Arthritis, where symptoms follow predictable daily patterns.Recent
advancements in polymer science, nanotechnology, and smart drug delivery have enhanced the precision and
efficiency of pulsatile systems. Despite these benefits, challenges such as complex manufacturing processes, higher
costs, and potential variability in drug release remain significant concerns.In conclusion, pulsatile drug delivery
systems offer a promising approach to improving therapeutic outcomes by aligning drug release with physiological
needs. Continued research and technological innovation are expected to overcome current limitations and expand
their clinical applications, making PDDS an important focus in modern pharmaceutics.

Keywords: Pulsatile release, lag time delivery, chronotherapy, time-dependent systems, controlled drug release, stimuli-responsive systems, circadian rhythm targeting, site-specific delivery, smart drug carriers, delayed release formulations.