GREEN FORMULATION STRATEGY FOR COST-EFFECTIVE POROUS TABLETS OF AMLODIPINE BESYLATE

Pratham Singh, Anuj Yadav, Ankur Awasthi, Bhupendra Mourya, Dr. Akash Yadav*, Dr. Dinesh Kumar Jain

ABSTRACT

Hypertension is a chronic heart disease, and its management is a must by the use of pharmacological agents. A calcium channel blocker in the form of amlodipine besylate is a very popular drug in the management of high blood pressure and angina. However, the traditional pills or tablets may create a problem in swallowing for geriatric, paediatric, and dysphagic patients, and thus may result in adverse effects on patient compliance. A patient-friendly option is available in the form of porous tablets, also known as oro dispersible tablets, which easily disintegrate in the mouth cavity and do not require the use of water. The purpose of this study is to plan and look into cost-effective porous amlodipine besylate tablets prepared through the direct compression method. Various formulations have been prepared using the commonly used superdisintegrants in varying ratios. Pre-compression and post-compression characteristics, wetting time, in-vitro dissolution, disintegration time, and content uniformity of the produced tablets have all been assessed. This composition led to good physicochemical properties. The optimized composition possessed good properties such as rapid dissolution, uniform distribution of the drug, mechanical strength, and rapid release of the drug. Based on this composition, concluded that the direct compression technique is simple and cost-effective for the preparation of porous amlodipine besylate tablets that may help to increase patient compliance in the treatment of hypertension.

Keywords: Amlodipine besylate, porous tablets, Oro-dispersible tablets, direct compression, super