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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Ram Niwas Jangir and Gyan Chand Jain*


The present study aimed to evaluate antidiabetic and antioxidant activities of 70% ethanolic extract of Moringa oleifera leaves (MOLEt) in streptozotocin-induced diabetic rats. Diabetes was induced in male Wistar rats by single intraperitoneal injection of streptozotocin (60 mg/kg b.wt.). The diabetic rats were administered orally with MOLEt at three different doses (100, 250 and 500 mg/kg b.wt./day) for 60 days. The results were compared with glibenclamide (5 mg/kg b.wt./day) treated rats. The streptozotocin treated control rats showed a significant increase in fasting blood glucose and glycosylated hemoglobin (HbA1c) with a concomitant decrease in serum insulin level and glycogen content in liver. Moreover, the levels of lipid peroxide (TBARS) in pancreatic tissue were significantly increased with a concurrent decline in antioxidant markers (SOD, CAT, GSH and ascorbic acid). The histopathological picture of the pancreatic islets showed degenerative and atrophic changes. Oral administration of MOLEt (100, 250 and 500 mg/kg b.wt./day) or glibenclamide for 60 days showed significant reduction in blood glucose and HbA1c levels and an elevation in serum insulin and hepatic glycogen levels. The extract treatment also reduced TBARS levels and improved the levels of antioxidant markers in the pancreas. The histomorphological picture of pancreas in MOLEt treated diabetic rats showed marked sign of amelioration. These results were comparable to reference drug, glibenclamide. The results of present study showed that MOLEt posseses significant antidiabetic and antioxidant activities.

Keywords: Antioxidant, Blood glucose, Insulin, Pancreas, Moringa oleifera, Streptozotocin.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia