A CLINICAL STUDY OF A TOPICAL NONPHARMACOPEAL OINTMENT IN THE MANAGEMENT OF DERMATOPHYTIC INFECTION

Sawood Ahmad*, Mohd. Mohsin

ABSTRACT

Introduction: Dermatophyte is a group of superficial mycosis produced by dermatophytes, of which belonged to Genera of Epidermophyton, Trichophyton and Microsporum. Cutaneous dermatophytic infection is limited to the superficial layer of the epidermis. Warm and humid climate is a favourable environment for the organisms causing the superficial dermatophytic Infection. The dermatophytes which infect only keratinized structures such as skin, hairs and nails. Material Methods: Study was conducted on 100 patients of dermatophytic infection attending the Skin OPD of the A, K, T, C, and Hospital A.M.U Aligarh, during the period from July 2017 to June 2019. Before the clinical trial ethical clearance was obtained from the Ethics committee. The patients were selected on the basis of history, physical examination, and investigations. The diagnosis was confirmed on the basis of KOH examination of skin. Results: In group A, itching was found to have improved in 32 patients, while in group B the itching was found to have improved in 34 patients out of 50 patients in each group. In which 40 patients of group A reported improvement while in group B 37 patients reported improvement in erythema. Both the drugs were equally effective in the management of dermatophytosis. Discussion: The findings of the clinical study demonstrated that the topical application of the test drug i.e. ointment in the patients of dermatophytosis produced significant effect. The symptomatic relief was observed in almost all patients, while 70% recovery was found in KOH examination. After the complete treatment 66% patients of the test group and 74% patients of standard group were found KOH negative after the completion of treatment duration. Conclusion: The test drug in the form of the ointment is effective in the management of dermatophytosis. It is able to ameliorate the signs and symptoms of dermatophytosis including itching, erythema, vesicles, papules, and scaly successfully.

Keywords: Dermatophytic Infection, KOH Examination, prevalence rate.