A NEW DISCOVERY TOWARDS NOVEL SKELETON OF BENZIMIDAZOLE AS UNIQUE EFFECTIVE ANTIMICROBIAL AGENTS

*Dr. Ojas Patel, Dr. Mona Patel, Ms. Sanjana Patel, Ms. Suhani Patel, Mr. Priyank Patel, Ms. Neha Patel, Mr. Pratik Patel

ABSTRACT

This study has been successfully synthesized two novel benzimidazole derivatives via a two-step reaction process in which o-phenylenediamine was reacted with acetic acid and formic acid to obtain 2-methylbenzimidazole and benzimidazole, respectively, followed by N-alkylation with benzyl chloride to produce N-benzyl-2-methylbenzimidazole and 1-benzylbenzimidazole. The synthesized compounds were purified and characterized by standard methods and further evaluated for antimicrobial activity using the agar well diffusion method. The biological results were compared against the standard drug tetracycline and showed moderate antimicrobial activity against selected microbial strains.

Keywords: Benzimidazole, N-alkylation, Antimicrobial, Agar well diffusion method, Tetracyclines a strong case for adding BCM to standard dialysis care worldwide, especially in regions where healthcare resources are limited.