PHYSIOCHEMICAL EVALUATION AND STANDARDIZATION OF VIBHITAKADI EYE OINTMENT

Dr. Sheena Babu*, Dr. Mamatha K. V., Dr. Chandana P.

ABSTRACT

Drug standardization is essential to ensure the quality, efficacy, and authenticity of pharmaceutical preparations. Vibhitakadi Ghrita, described in Yogaratnakara, has been found to be effective in the management of Shushkakshipaka. The formulation comprises Vibhitaki, Haritaki, Amalaki, Nimba, Patola, Vasa, and Go Ghrita. In the present study, this GhIrita-based formulation was modified into an ointment form to enhance bioavailability and improve ocular absorption The present analytical study was undertaken to standardize Vibhitakadi eye ointment and to establish its organoleptic, physicochemical, chromatographic, and microbial quality parameters. The results revealed that the formulation possesses suitable physicochemical characteristics, including neutral pH, low moisture content, satisfactory spreadability, and overall stability. Microbial evaluation further confirmed the complete absence of bacterial and fungal contamination, indicating the formulation’s safety for ocular use. Collectively, these findings support the successful standardization of Vibhitakadi eye ointment and affirm its suitability as an ophthalmic preparation for the management of Shushkakshipaka (Digital Eye Strain).

Keywords: Vibhitakadi Eye Ointment, Standardization, HPTLC.