PHARMACOGNOSTICAL AND PHARMACEUTICAL ANALYSIS OF SHULADWIPAGHNI VATI: A HERBOMINERAL FORMULATION

Sathi E. D.*, Sanila V. K.

ABSTRACT

Background: Herbomineral formulations are widely used in traditional medicine and are considered beneficial for
managing chronic diseases when properly processed. Owing to their combined herbal and mineral constituents,
such formulations often exhibit significant anti-inflammatory and antioxidant properties. Shuladwipaghni vati is
one such formulation that comprises ingredients individually known for these therapeutic potentials, suggesting its
possible role in chronic inflammatory conditions. Systematic evaluation of its pharmacognostical characteristics
and pharmaceutical processing is essential to establish standardisation parameters and provide a scientific basis for
further research. Methods: Shuladwipaghni vati was prepared using authenticated and genuine raw drugs. As part
of pharmacognostical evaluation, for herbal drugs, macroscopical and microscopical evaluation was performed,
and for mineral drugs, XRD analysis was conducted. In pharmaceutical evaluation, physicochemical analysis and
instrumental analysis were carried out. Results: The microscopic features of herbal drugs were compared with the
standards of individual drugs mentioned in the Ayurvedic Pharmacopoeia of India. Mineral identification was
performed using XRD analysis. HPTLC revealed 9 peaks at ultraviolet 254 nm and 7 peaks at ultraviolet 366 nm,
indicating a diverse range of phytoconstituents. ICP-OES heavy metal analysis detected cadmium (0.06 ppm) and
mercury (0.19 ppm) within permissible limits of the Ayurvedic Pharmacopoeia of India. XRD analysis confirmed
the presence of Sulphur, Halite, Boron, and Magnesium sulphite hydrate. FTIR showed peaks indicating OH, C=O,
C-H, and C-O stretching. ICP-MS analysis detected Mg (0.29%), K(0.69%), Ca(0.08%), Mn(74.04 ppm), Cu
(113.28 ppm), Zn (21.53 ppm), and Fe(96.22 ppm). Conclusion: The findings establish a scientific baseline for
standardisation and future research on Shuladwipaghni vati.

Keywords: Shuladwipaghni vati, Standardisation, Pharmacognostical evaluation, Pharmaceutical evaluation, Physicochemical analysis, Instrumental analysis, Ayurvedic Pharmacopoeia of India.