STUDY OF ANTIMITOTIC ACTIVITY OF FLACOURTIA JANGOMAS LEAVES BY USING ALLIUM CEPA ROOT TIP ASSAY

Mrs. Mintumol Babu, Akash Krishna, Aswathy Ajayakumar, Francis Joseph, Neena Johnson*

ABSTRACT

Objective: Cancer is still a serious worldwide health issue that calls for the investigation of new treatment options. Medicinal plants have been identified as possible sources of anticancer chemicals via phytochemical study. The Allium cepa root tip assay was used in this study to assess the antimitotic efficacy of an aqueous leaf extract of Flacourtia jangomas(family: Flacourtiaceae). The Soxhlet extraction method was used to extract dried leaves using an aqueous solvent. Methotrexate was the standard medication used to measure antimitotic activity in Allium cepa roots. When compared to the control (distilled water), the aqueous leaf extract (10 mg/ml) significantly inhibited root growth and the mitotic index in a concentration-dependent manner. The findings show significant cytotoxic and antimitotic effects, which are probably caused by the presence of phenolic chemicals, alkaloids, and flavonoids. These results imply that the leaves of Flacourtia jangomas contain bioactive components that may have anticancer effects and call for more research. Conclusion: The current study found that the leaves of Flacourtia jangomas contain some significant chemical components that may be extracted using water as a solvent and used in the management of cancer treatment.

Keywords: Allium cepa, flacourtia jangomas, Flacourtiaceae, Soxhlet extraction, flavonoids, alkaloids and phenolic compounds.