EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

COMPARATIVE EFFICACY OF ROSUVASTATIN AND ATORVASTATIN IN PATIENTS WITH CORONARY ARTERY DISEASE

Akhilendran R., Hima Mahesh, Fahida Farook, Swathi M., Pradeep P., Veena Vijayan G.*

ABSTRACT

The objective of study was to compare the lipid lowering efficacy of Atorvastatin and Rosuvastatin in Coronary Artery Disease patients. In this study we analyzed data of 130 patients of IP and OP department of tertiary care hospital in south Kerala over a period of 6 months. Patients above 18yrs of age presenting with coronary artery disease and dyslipidemia were included in this study. The lipid profile values were noted and rechecked at an interval of 6 weeks to compare the efficacy of Atorvastatin and Rosuvastatin. Atorvastatin 20mg was comparable to Rosuvastatin 10mg. According to the doseresponse analysis, mean differences between the LDL, Triglyceride and Total cholesterol dose responses of Rosuvastatin 10 to 40mg versus Atorvastatin 10 to 40mg were significant. HDL C increasing effect of Rosuvastatin at doses of 10, 20, 40mg were found to be comparatively higher than Atorvastatin at similar doses after 6 weeks of treatment. Across dose ranges HDL C increasing effect was found to be rising with dose with both statins. The best LDL C, Triglyceride and Total Cholesterol reductions with Rosuvastatin were obtained at dose of 40mg. The study concluded with the findings that Rosuvastatin was found to be more efficacious in lowering LDL level compared to Atorvastatin.

Keywords: Comparative study, Atorvastatin, Rosuvastatin, Dyslipidemia.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia