EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

CLINICAL EFFICACY OF ISOBARIC ROPIVACAINE ALONE AND WITH FENTANYL IN SPINAL ANAESTHESIA FOR VAGINAL HYSTERECTOMY: A PROSPECTIVE, RANDOMIZED, COMPARATIVE STUDY

Dr. Devendra Verma, *Dr. Ankush Kumar Garg, Dr. Udita Naithani, Dr. Smita Barya, Dr. Pradeep Bugaliya, Dr. Vikas Sharma

ABSTRACT

BACKGROUND: Aim of this study was to assess the clinical efficacy of 4 ml of 0.75% ropivacaine alone and with 25mcg fentanyl in spinal anaesthesia for vaginal hysterectomy regarding sensory and motor block characteristics, success rate, haemodynamic profile and complications. METHODS: Present study was conducted in a randomized double blind fashion on 60 patients, 30 in each group of ASA physical status I-II posted for vaginal hysterectomy. All patients under study were randomly divided into two groups of 30 patients in each group using sealed envelope technique. GROUP R: Patients received 4 ml 0.75% Isobaric Ropivacaine hydrochloride [Ropin (neon labs)] GROUP RF: Patients received 4ml 0.75% Isobaric Ropivacaine [Ropin (neon labs)] with 25µg Fentanyl hydrochloride [Fenstud] We evaluated whether addition of fentanyl to intrathecal ropivacaine could make a significant effect on onset and duration of analgesia, sensory and motor block. RESULTS • Isobaric Ropivacaine [4 ml 0.75% (30 mg)] alone and with fentanyl (25mcg) in spinal anaesthesia produced effective sensory-motor blockade of sufficient duration with stable hemodynamic profile to accomplish vaginal hysterectomy. • Addition of fentanyl offered the advantage of accelerating the sensory onset and prolonging the duration of analgesia and sensory block, without affecting sympathetic or motor block characteristics. CONCLUSIONS: Owing to early recovery in motor functions and lesser cardio-neuro toxicity, ropivacaine seems to be a good option for spinal anaesthesia.

Keywords: Isobaric Ropivacaine, Fentanyl, Spinal Anaesthesia, Vaginal Hysterectomy.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia