ORAL MUCOADHESIVE GEL: A NOVEL APPROACH IN DRUG DELIVERY SYSTEM

K. V. Khangar*, Dr. A.D. Kajale- Kulkarni

ABSTRACT

Mucoadhesive oral gels are emerging as an innovative and effective drug delivery system designed to adhere to the mucosal surface of the oral cavity, enabling prolonged residence time and enhanced bioavailability. These systems are particularly advantageous for the local or systemic delivery of drugs that require sustained release or targeted action. This study focuses on the formulation and evaluation of a mucoadhesive oral gel containing drug, aimed at the treatment of disease/condition, e.g., oral inflammatory pain. The gel incorporates mucoadhesive polymers to ensure strong adhesion and controlled drug release. In vitro and in vivo assessments demonstrate improved therapeutic efficacy, enhanced patient compliance, and reduced dosing frequency. Recent advancements focus on incorporating bio-adhesive polymers, penetration enhancers, and nanocarriers to optimize drug release profiles and mucosal permeability. Using various methods for preparation of oral mucoadhesive gel, a uniform gel base must be prepared using mucoadhesive polymers, into which the drug should be incorporated. The evaluation for physicochemical properties, mucoadhesive strength, drug content, and in-vitro release should be performed. This novel delivery system holds significant potential for the management of various oral and systemic diseases. This review provides a comprehensive overview of the principles, formulation strategies, and evaluation parameters associated with oral mucoadhesive gel systems. It highlights the mechanisms of mucoadhesion, commonly employed polymers, and the physicochemical considerations essential for achieving optimal gel performance. Overall, the findings support the use of mucoadhesive gels as an effective platform for oral drug delivery.

Keywords: Mucoadhesive oral gel, Buccal drug delivery, Oral gel, Mucoadhesive polymers, Controlled drug release, Oral inflammatory pain.