EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , Doi-Digital Online Identifier , ISSN National Centre , Zenodo Indexing , International CODEN Service, USA ,

ISSN (O) : 2394-3211

ISSN (P) : 3051-2573

Impact Factor: 7.065

ICV - 79.57

Abstract

HEPATITIS B VACCINE FAILURE: A SYSTEMATIC REVIEW OF GENETIC, IMMUNOLOGICAL, AND BEHAVIORAL CONTRIBUTORS TO NON-IMMUNITY, POST HEPATITIS B VACCINATION

Dr. Lukong Hubert Shalanyuy*, Pr Samje Moses, Dr. Tanlaka Lucas Mengnjo, Wam Elvis Chongsi,
Leonard Nyuyseni Randze, Gewun Braindaline, Dor Mari Claire Wiydzerla, Lukong Jude Thaddeus Veranso, Fongum Evans Kobbi

ABSTRACT

Background: Hepatitis B virus (HBV) remains a major global public health problem despite highly effective vaccines. While most recipients develop protective anti-HBs antibody titres (≥10 mIU/mL), a minority fail to seroconvert, posing risks for ongoing transmission. This systematic review quantified the prevalence of hepatitis B vaccine non-response and evaluated genetic, immunological, behavioral, and clinical determinants. Methods: Following PRISMA 2020 guidelines, we searched PubMed/MEDLINE, EMBASE, Scopus, Web of Science, CINAHL, Cochrane Library, African Index Medicus, and gray literature up to November 2025. Eligible studies included RCTs, cohort, case-control, cross-sectional, and genetic association studies reporting post-vaccination anti-HBs titres. Non-response was defined as anti-HBs

Keywords: While most recipients develop protective anti-HBs antibody titres (?10 mIU/mL), a minority fail to seroconvert, posing risks for ongoing transmission.

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SJIF Impact Factor: 7.065

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	All	Since 2019
Citation	3086	2560
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NEWS & UPDATION

EJPMR: JANUARY ISSUE PUBLISHED
JANUARY 2026 issue has been successfully launched on 1 JANUARY 2026.

New Issue Published
Its Our pleasure to inform you that, EJPMR 1 January 2026 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

EJPMR New Impact Factor
EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

Index Copernicus Value
EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

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EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH