DRUG-INDUCED (ATT) HEPATITIS WITH LEFT HYDROURETERONEPHROSIS AND COPD WITH SYNPNEUMONIC EFFUSION: A CASE REPORT

Polu Saimamatha*, Mekla Anusha

ABSTRACT

Drug-induced hepatitis is a major adverse effect associated with antitubercular therapy (ATT), particularly when
isoniazid, rifampicin, and pyrazinamide are used concurrently. This case report discusses a 59-year-old male
diagnosed with pulmonary tuberculosis who developed drug- induced (ATT) hepatitis during therapy, along with
left hydroureteronephrosis, chronic obstructive pulmonary disease (COPD), and synpneumonic effusion. The
patient presented with fever, shortness of breath, dry cough, and jaundice. Laboratory investigations revealed
elevated liver enzymes and bilirubin, while imaging showed bilateral renal calculi and pleural effusion. Treatment
involved discontinuation of hepatotoxic drugs, initiation of supportive management, and close monitoring. The
case highlights the importance of early detection and management of ATT-induced hepatotoxicity to prevent
irreversible liver injury.

Keywords: ATT-induced hepatitis, Hepatotoxicity, Tuberculosis, Hydroureteronephrosis, COPD, Pleural effusion.